Update on Ghrelin
نویسندگان
چکیده
1Digestive System and Nutrition Laboratory (ADEN EA4311), Biomedical Research Institute, IFR23, Rouen 76183, France 2Department of Clinical Medicine, Sapienza University, 00189 Rome, Italy 3Department of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL 32611, USA 4Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520, Japan
منابع مشابه
Ghrelin: update on a novel hormonal system.
Ghrelin is a peptide hormone secreted into the circulation from the stomach but also synthesised in a number of tissues, suggesting both endocrine and paracrine effects. These include: stimulation of GH, prolactin and ACTH secretion; an increase in appetite; a diabetogenic effect on carbohydrate metabolism; positive inotropic effects on heart; vasodilatation; and effects on cell proliferation. ...
متن کاملGhrelin O-Acyl Transferase: Bridging Ghrelin and Energy Homeostasis
Ghrelin O-acyl transferase (GOAT) is a recently identified enzyme responsible for the unique n-acyl modification of ghrelin, a multifunctional metabolic hormone. GOAT structure and activity appears to be conserved from fish to man. Since the acyl modification is critical for most of the biological actions of ghrelin, especially metabolic functions, GOAT emerged as a very important molecule of i...
متن کاملThe Effect of Central Injection of Ghrelin and Bombesin on Mean Plasma Thyroid Hormones Concentration
Ghrelin increases food intakes and body weight. Bombesin decreases food intakes and inhibits the stimulatory effect of Ghrelin on food intakes. Thyroid hormones have a crucial role in the regulation of body weight and yet the effect of bombesin on thyroid axis activity is not fully clear. Therefore, the goal of this study was to determine the effect of different doses of Ghrelin or bombesin on ...
متن کاملThe effects of interactions between testosterone and ghrelin on mean plasma thyroid hormones concentration in male rats
Ghrelin is an orexigenic peptide synthesized mainly by stomach and hypothalamus. Ghrelin decreases secretion of thyroid hormones. Testosterone is an esteroidogenic hormone that exerts stimulatory effects on Hypothalamus-Pituitary-Thyroid (HPT) axis activity. The aim of the present study was to investigate the effect of interactions between the central injection of ghrelin and testosterone on me...
متن کاملRole of Central Cannabinoidergic System on Ghrelin-Induced Hypophagia in Layer-Type Neonatal Chicken
Background: Feeding behavior is regulated via a complex network which interacts through diverse signals from central and peripheral tissues. OBJECTIVES: The main purpose of the current study was to determine the role of central cannabinoidergic (CBergic) system on ghrelin-induced hypophagia in 3-h food deprived (FD3) neonatal chicken. METHODS: In experiment 1, chicks were ICV injected with cont...
متن کاملDetermination of the effect of the interaction between Ghrelin and serotonin agonist (R)-8-OH-DPAT on the mean plasma concentrations of T3 & T4 in rat
Introduction: Previous studies have shown that ghrelin inhibits the activity of Hypothalamus –Pituitary – Thyroid (H–P-T) axis. It is also proved that ghrelin increases appetite via Agouti Related Protein and neuropeptide Y pathway, decreases T3 & T4 secretion and inhibits serotonin release from hypothalamic synaptosomes. Serotonin may interact with ghrelin in control of thyroid hormones secr...
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ورودعنوان ژورنال:
دوره 2010 شماره
صفحات -
تاریخ انتشار 2010